Abstract: Anti-（vascular endothelial growth factor，VEGF） is a first-line treatment for many retinal vascular diseases leading to macular edema. In clinical practice, repeated intraocular injections is required to achieve therapeutic effects. Intraocular injection is safety, and only few complications such as elevated intraocular pressure and intraocular inflammation have been reported. In recent years, clinicians have gradually begun to pay attention to the effects of repeated injections of anti-VEGF drugs on cornea. It has been reported that anti-VEGF drugs may affect corneal epithelium, corneal endothelium, corneal nerve, corneal biomechanics, dry eye and other aspects, which should be paid attention to by ophthalmologists.

Key words: vascular endothelial growth factor, cornea